Moreover, it plays the largest roles out of all the methyltransferases, when it comes to the maintaining the epigenome. Next, when it comes to DNA methyltransferases 3A and 3B, one of the biggest distinctions that can be made between the two has to do with the rate at which they add methyl groups to the base pair cytosine. DNA methyltransferase 3A can methylate cytosines faster than DNA methyltransferase 3B, but DNA methyltransferase 3A performs methylation at a slower rate than DNA methyltransferase 1.
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